Effect of Trimethoprim-sulphamethoxazole on Typhoid and Salmonella Carriers

Effect of trimethoprim-sulphamethoxazole on typhoid and salmonella carriers.

Four chronic typhoid carriers from the Aberdeen typhoid outbreak of 1964 were treated with trimethoprim-sulphamethoxazole. The male carrier remained clear of infection following treatment but the three female carriers, all with gall bladder abnormalities, remained excretors. A convalescent typhoid excretor also remained clear of infection after treatment as well as two other salmonella carriers...

Treatment of chronic urinary salmonella carriers with trimethoprim-sulphamethoxazole.

Trimethoprim and sulphamethoxazole in typhoid fever in children.

One hundred and three children with proved typhoid fever were treated with trimethoprim-sulphamethoxazole, and the results compared with those of a further 40 children treated with chloramphenicol. The bacteriological response to trimethoprim-sulphamethoxazole was unsatisfactory. From this study it seems that at present chloramphenicol is still the treatment of choice for typhoid fever. In view...

Effect of thymidine on activity of trimethoprim and sulphamethoxazole.

Thymidine at levels as low as 0.05 mg/1 reduces the activities of sulphamethoxazole and trimethoprim and their combination in vitro. Using a biological assay procedure, levels of thymidine greater than this were interpreted as being present in urine. The addition of sulphamethoxazole and trimethoprim, singly or in combination, to urine obtained from patients with urinary tract infections showed...

Treatment of Salmonella paratyphi A osteomyelitis with trimethoprim-sulphamethoxazole.